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Sedating dose

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Accumulation of normeperidine, a metabolite of meperidine, can precipitate seizures.Seizures have occurred after less than twenty-four hours of meperidine with less than 400mg Loading Dose The loading dose accelerates attainment of an effective blood level of the opioid at the initiation of therapy or for procedures.Since there is marked inter-patient variability in the amount of analgesic required for pain relief, the loading dose must be titrated to effect.Many studies have demonstrated a five fold variability in the quantity of intravenous opioid required to produce equivalent analgesia after surgery.However, now its marketing status is "Discontinued".Celexa (Citalopram hydrobromide) was approved by the FDA in July 17, 1998.Clonazepam belongs to a group of drugs called benzodiazepines.Benzodiazepines are medications that help relieve nervousness, tension, symptoms of anxiety, and some types of seizures by slowing the central nervous system.

The SSRIs represent the first rationally designed class of psychotropic medications.

An effective PCA program requires bedside nurses, physicians and pharmacists to monitor and titrate PCA settings based on adequacy of pain control, sedation, and other side-effects.

Meperidine (not available for PCA at Duke) Meperidine is not available for PCA therapy.

Dependent users may get withdrawal symptoms ranging from restlessness and insomnia to convulsions and death.

The drug works by slowing down both the heart and lung rate, and can cause a heart attack or lung problems if given in very high doses.